8TWY

Structure of PIK3CA with covalent inhibitor ALO26

8TWY の概要

• エントリーDOI: 10.2210/pdb8twy/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 1-(4-{[2-(4-{(4P)-4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethoxy]methyl}piperidin-1-yl)prop-2-en-1-one (2 entities in total)
• 機能のキーワード: pi3k, pik3ca, lipid kinase, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110586.82

構造登録者

Burke, J.E.,Barlow-Busch, I. (登録日: 2023-08-21, 公開日: 2024-08-28)

• 主引用文献: Burke, J.E.,Barlow-Busch, I.; Structure of PIK3CA with covalent inhibitor ALO26; To Be Published,

実験手法

X-RAY DIFFRACTION (2.67 Å)