8TU2

The Capsid of Rat Bocavirus

これはPDB形式変換不可エントリーです。

8TU2 の概要

• エントリーDOI: 10.2210/pdb8tu2/pdb
• EMDBエントリー: 41614 41615 41616
• 分子名称: VP2 (1 entity in total)
• 機能のキーワード: parvovirus, rbov, rat bocavirus, capsid, virus
• 由来する生物種: Rat bocavirus
• タンパク質・核酸の鎖数: 60
• 化学式量合計: 3812444.04

構造登録者

Velez, M.,Mietzsch, M.,McKenna, R. (登録日: 2023-08-15, 公開日: 2023-08-30, 最終更新日: 2025-05-21)

主引用文献

Velez, M.,Mietzsch, M.,Hsi, J.,Bell, L.,Chipman, P.,Fu, X.,McKenna, R.
Structural Characterization of Canine Minute Virus, Rat and Porcine Bocavirus.
Viruses, 15:-, 2023

PubMed Abstract: is an expansive genus of the , with a wide range of vertebrate hosts. This study investigates Canine minute virus (CnMV), Rat bocavirus (RBoV), and Porcine bocavirus 1 (PBoV1). Both CnMV and PBoV1 have been found in gastrointestinal infections in their respective hosts, with CnMV responsible for spontaneous abortions in dogs, while PBoV has been associated with encephalomyelitis in piglets. The pathogenicity of the recently identified RBoV is currently unknown. To initiate the characterization of these viruses, their capsids structures were determined by cryo-electron microscopy at resolutions ranging from 2.3 to 2.7 Å. Compared to other parvoviruses, the CnMV, PBoV1, and RBoV capsids showed conserved features, such as the channel at the fivefold symmetry axis. However, major differences were observed at the two- and threefold axes. While CnMV displays prominent threefold protrusions, the same region is more recessed in PBoV1 and RBoV. Furthermore, the typical twofold axis depression of parvoviral capsids is absent in CnMV or very small in PBoV and RBoV. These capsid structures extend the structural portfolio for the genus and will allow future characterization of these pathogens on a molecular level. This is important, as no antivirals or vaccines exist for these viruses.

PubMed: 37766206
DOI: 10.3390/v15091799

実験手法

ELECTRON MICROSCOPY (2.52 Å)