8TTZ

Crystal structure of monkey TLR7 ectodomain with compound 20

8TTZ の概要

• エントリーDOI: 10.2210/pdb8ttz/pdb
• 分子名称: Toll-like receptor 7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: toll-like receptor 7, immune system
• 由来する生物種: Macaca mulatta (Rhesus monkey)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 195710.05

構造登録者

Critton, D.A. (登録日: 2023-08-15, 公開日: 2024-02-07, 最終更新日: 2024-02-28)

• 主引用文献: Poudel, Y.B.,He, L.,Cox, M.,Zhang, Q.,Johnson, W.L.,Cong, Q.,Cheng, H.,Chowdari, N.S.,Tarby, C.,Donnell, A.F.,Broekema, M.,O'Malley, D.P.,Zhang, Y.,A M Subbaiah, M.,Kumar, B.V.,Subramani, L.,Wang, B.,Li, Y.X.,Sivaprakasam, P.,Critton, D.,Mulligan, D.,Sandhu, B.,Xie, C.,Ramakrishnan, R.,Nagar, J.,Dudhgaonkar, S.,Oderinde, M.S.,Murtaza, A.,Schieven, G.L.,Mathur, A.,Gavai, A.V.,Vite, G.,Gangwar, S.; Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.; Acs Med.Chem.Lett., 15:181-188, 2024; PubMed: 38352830; DOI: 10.1021/acsmedchemlett.3c00455

実験手法

X-RAY DIFFRACTION (3.14 Å)