8TTN

PHF1-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S396E, S400E, T403E, S404E)

Summary for 8TTN

Entry DOI	10.2210/pdb8ttn/pdb
EMDB information	41611
Descriptor	Microtubule-associated protein tau (1 entity in total)
Functional Keywords	tau, amyloid fibril, phosphomimetic, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	5
Total formula weight	201139.86
Authors	El Mammeri, N.,Dregni, A.J.,Duan, P.,Hong, M. (deposition date: 2023-08-14, release date: 2024-06-26)
Primary citation	Mammeri, N.E.,Dregni, A.J.,Duan, P.,Hong, M. Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation. Proc.Natl.Acad.Sci.USA, 121:e2316175121-e2316175121, 2024 Cited by PubMed: 38408247 DOI: 10.1073/pnas.2316175121 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.4 Å)

Structure validation