8TR5
Cryo-EM structure of the rat P2X7 receptor in the apo closed state
Summary for 8TR5
Entry DOI | 10.2210/pdb8tr5/pdb |
Related | 8TRJ 8V4S |
EMDB information | 41570 41581 42976 |
Descriptor | P2X purinoceptor 7, GUANOSINE-5'-DIPHOSPHATE, ZINC ION, ... (7 entities in total) |
Functional Keywords | membrane protein, ion channel, ligand-gate ion channel, p2x receptor, allosteric antagonist, high-affinity agonist |
Biological source | Rattus More |
Total number of polymer chains | 3 |
Total formula weight | 212999.66 |
Authors | Oken, A.C.,Lisi, N.E.,Krishnamurthy, I.,McCarthy, A.E.,Godsey, M.H.,Glasfeld, A.,Mansoor, S.E. (deposition date: 2023-08-09, release date: 2024-08-14) |
Primary citation | Oken, A.C.,Lisi, N.E.,Krishnamurthy, I.,McCarthy, A.E.,Godsey, M.H.,Glasfeld, A.,Mansoor, S.E. High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket Nat Commun, 2024 Cited by DOI: 10.1038/s41467-024-50771-6PDB entries with the same primary citation |
Experimental method |
Structure validation
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