8TK9

ZIG-4-INS-6 complex, tetragonal form

8TK9 の概要

• エントリーDOI: 10.2210/pdb8tk9/pdb
• 分子名称: Zwei Ig domain protein zig-4, Probable insulin-like peptide beta-type 5, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: neuropeptide, signaling protein, protein binding, signaling protein-protein binding complex, signaling protein/protein binding
• 由来する生物種: Caenorhabditis elegans; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30375.11

構造登録者

Cheng, S.,Baltrusaitis, E.,Aziz, Z.,Nawrocka, W.I.,Ozkan, E. (登録日: 2023-07-25, 公開日: 2024-08-28, 最終更新日: 2024-10-16)

主引用文献

Nawrocka, W.I.,Cheng, S.,Hao, B.,Rosen, M.C.,Cortes, E.,Baltrusaitis, E.E.,Aziz, Z.,Kovacs, I.A.,Ozkan, E.
Nematode Extracellular Protein Interactome Expands Connections between Signaling Pathways.
Biorxiv, 2024

PubMed Abstract: Multicellularity was accompanied by the emergence of new classes of cell surface and secreted proteins. The nematode is a favorable model to study cell surface interactomes, given its well-defined and stereotyped cell types and intercellular contacts. Here we report our extracellular interactome dataset, the largest yet for an invertebrate. Most of these interactions were unknown, despite recent datasets for flies and humans, as our collection contains a larger selection of protein families. We uncover new interactions for all four major axon guidance pathways, including ectodomain interactions between three of the pathways. We demonstrate that a protein family known to maintain axon locations are secreted receptors for insulins. We reveal novel interactions of cystine-knot proteins with putative signaling receptors, which may extend the study of neurotrophins and growth-factor-mediated functions to nematodes. Finally, our dataset provides insights into human disease mechanisms and how extracellular interactions may help establish connectomes.

PubMed: 39026773
DOI: 10.1101/2024.07.08.602367

実験手法

X-RAY DIFFRACTION (1.3 Å)