8TFT

Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3

Summary for 8TFT

• Entry DOI: 10.2210/pdb8tft/pdb
• Descriptor: O-13-1 IgG1 Fab heavy chain, O-13-1 IgG1 Fab light chain, T-cell immunoglobulin mucin receptor 3, ... (5 entities in total)
• Functional Keywords: fragment antigen binding, antibody, t-cell immunoglobulin mucin receptor 3 (tim-3), igv type domain, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 118768.57

Authors

Oganesyan, V.Y.,van Dyk, N.,Mazor, Y.,Yang, C. (deposition date: 2023-07-11, release date: 2024-08-28)

• Primary citation: Clancy-Thompson, E.,Perry, T.,Pryts, S.,Jaiswal, A.,Oganesyan, V.,Moynihan, J.,van Dyk, N.,Yang, C.,Garcia, A.,Yu, J.,Miller, C.,Mulgrew, K.,Cobbold, M.,Mazor, Y.,Hammond, S.A.,Pollizzi, K.N.; Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3; To be published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)