8TFT
Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3
8TFT の概要
エントリーDOI | 10.2210/pdb8tft/pdb |
分子名称 | O-13-1 IgG1 Fab heavy chain, O-13-1 IgG1 Fab light chain, T-cell immunoglobulin mucin receptor 3, ... (5 entities in total) |
機能のキーワード | fragment antigen binding, antibody, t-cell immunoglobulin mucin receptor 3 (tim-3), igv type domain, immune system |
由来する生物種 | Homo sapiens 詳細 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 118768.57 |
構造登録者 | |
主引用文献 | Clancy-Thompson, E.,Perry, T.,Pryts, S.,Jaiswal, A.,Oganesyan, V.,Moynihan, J.,van Dyk, N.,Yang, C.,Garcia, A.,Yu, J.,Miller, C.,Mulgrew, K.,Cobbold, M.,Mazor, Y.,Hammond, S.A.,Pollizzi, K.N. Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3 To be published, |
実験手法 | X-RAY DIFFRACTION (2.3 Å) |
構造検証レポート
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