8TEX

Avian Adeno-associated virus - empty capsid

これはPDB形式変換不可エントリーです。

8TEX の概要

• エントリーDOI: 10.2210/pdb8tex/pdb
• EMDBエントリー: 41208
• 分子名称: Capsid protein (1 entity in total)
• 機能のキーワード: adeno-associated virus, capsid, quail bronchitis, avianaav, aaav, virus
• 由来する生物種: Avian adeno-associated virus
• タンパク質・核酸の鎖数: 60
• 化学式量合計: 3614250.00

構造登録者

Hsi, J.,Mietzsch, M.,Chipman, P.,Afione, S.,Zeher, A.,Huang, R.,Chiorini, J.,McKenna, R. (登録日: 2023-07-07, 公開日: 2023-08-30, 最終更新日: 2025-05-28)

主引用文献

Hsi, J.,Mietzsch, M.,Chipman, P.,Afione, S.,Zeher, A.,Huang, R.,Chiorini, J.,McKenna, R.
Structural and antigenic characterization of the avian adeno-associated virus capsid.
J.Virol., 97:e0078023-e0078023, 2023

PubMed Abstract: AAVs are extensively studied as promising therapeutic gene delivery vectors. In order to circumvent pre-existing antibodies targeting primate-based AAV capsids, the AAAV capsid was evaluated as an alternative to primate-based therapeutic vectors. Despite the high sequence diversity, the AAAV capsid was found to bind to a common glycan receptor, terminal galactose, which is also utilized by other AAVs already being utilized in gene therapy trials. However, contrary to the initial hypothesis, AAAV was recognized by approximately 30% of human sera tested. Structural and sequence comparisons point to conserved epitopes in the fivefold region of the capsid as the reason determinant for the observed cross-reactivity.

PubMed: 37702486
DOI: 10.1128/jvi.00780-23

実験手法

ELECTRON MICROSCOPY (2.54 Å)