8TD7

Structure of PYCR1 complexed with 2S-hydroxy-3-methylbutyric acid

8TD7 の概要

• エントリーDOI: 10.2210/pdb8td7/pdb
• 分子名称: Pyrroline-5-carboxylate reductase 1, mitochondrial, (2S)-2-hydroxy-3-methylbutanoic acid, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: amino-acid biosynthesis, oxidoreductase, proline biosynthesis, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 168839.96

構造登録者

Tanner, J.J.,Meeks, K.R. (登録日: 2023-07-02, 公開日: 2024-07-03, 最終更新日: 2024-09-18)

• 主引用文献: Meeks, K.R.,Bogner, A.N.,Tanner, J.J.; Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1).; Protein Sci., 33:e5072-e5072, 2024; PubMed: 39133178; DOI: 10.1002/pro.5072

実験手法

X-RAY DIFFRACTION (1.61 Å)