8TCW
Structure of PYCR1 complexed with 2-methyl-3-(2-oxoimidazolidin-1-yl)benzoic acid
Summary for 8TCW
Entry DOI | 10.2210/pdb8tcw/pdb |
Descriptor | Pyrroline-5-carboxylate reductase 1, mitochondrial, 2-methyl-3-(2-oxoimidazolidin-1-yl)benzoic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | amino-acid biosynthesis, oxidoreductase, proline biosynthesis |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 5 |
Total formula weight | 169340.37 |
Authors | Tanner, J.J.,Meeks, K.R. (deposition date: 2023-07-02, release date: 2024-03-06, Last modification date: 2024-03-20) |
Primary citation | Meeks, K.R.,Ji, J.,Protopopov, M.V.,Tarkhanova, O.O.,Moroz, Y.S.,Tanner, J.J. Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64:1704-1718, 2024 Cited by PubMed: 38411104DOI: 10.1021/acs.jcim.3c01879 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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