8TBR
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM758
Summary for 8TBR
Entry DOI | 10.2210/pdb8tbr/pdb |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(2-{3-[(2,4-diamino-6-phenylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (4 entities in total) |
Functional Keywords | ssgcid, structural genomics, seattle structural genomics center for infectious disease, dihydrofolate reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Mycobacterium ulcerans |
Total number of polymer chains | 1 |
Total formula weight | 20187.47 |
Authors | Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2023-06-29, release date: 2024-08-28) |
Primary citation | Woodward, E.L.,Lovell, S.,Mian, M.R.,Seibold, S. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM758 To be published, |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report