8T8I

Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions

8T8I の概要

• エントリーDOI: 10.2210/pdb8t8i/pdb
• 分子名称: VHH domain, Fab light chain, Fab heavy chain, ... (8 entities in total)
• 機能のキーワード: nabfab, nanobody, antibody fragment, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 63427.88

構造登録者

Filippova, E.V.,Thompson, I.,Kossiakoff, A.A. (登録日: 2023-06-22, 公開日: 2023-11-29, 最終更新日: 2024-01-03)

• 主引用文献: Bruce, H.A.,Singer, A.U.,Filippova, E.V.,Blazer, L.L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.H.,Mao, D.Y.L.,Pau, V.,Orlicky, S.,Sicheri, F.,Kurinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S.; Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.; Protein Sci., 33:e4824-e4824, 2024; PubMed: 37945533; DOI: 10.1002/pro.4824

実験手法

X-RAY DIFFRACTION (2.52 Å)