8T7N

Crystal structure of the R132H mutant of IDH1 bound to compound 1

Summary for 8T7N

• Entry DOI: 10.2210/pdb8t7n/pdb
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide, ... (4 entities in total)
• Functional Keywords: oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 98385.05

Authors

Lu, J.,Abeywickrema, P.,Heo, M.R.,Parthasarathy, G.,McCoy, M.,Soisson, S.M. (deposition date: 2023-06-20, release date: 2024-08-28)

• Primary citation: McCoy, M.A.,Lu, J.,Miller, R.,Soisson, S.M.,Lam, M.H.,Fischer, C.; Mechanistic and Biostructural Studies of Mutant IDH1; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.26 Å)