8T7N
Crystal structure of the R132H mutant of IDH1 bound to compound 1
Summary for 8T7N
Entry DOI | 10.2210/pdb8t7n/pdb |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide, ... (4 entities in total) |
Functional Keywords | oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 98385.05 |
Authors | Lu, J.,Abeywickrema, P.,Heo, M.R.,Parthasarathy, G.,McCoy, M.,Soisson, S.M. (deposition date: 2023-06-20, release date: 2024-08-28) |
Primary citation | McCoy, M.A.,Lu, J.,Miller, R.,Soisson, S.M.,Lam, M.H.,Fischer, C. Mechanistic and Biostructural Studies of Mutant IDH1 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
Download full validation report