8T7N

Crystal structure of the R132H mutant of IDH1 bound to compound 1

8T7N の概要

• エントリーDOI: 10.2210/pdb8t7n/pdb
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98385.05

構造登録者

Lu, J.,Abeywickrema, P.,Heo, M.R.,Parthasarathy, G.,McCoy, M.,Soisson, S.M. (登録日: 2023-06-20, 公開日: 2024-08-28)

• 主引用文献: McCoy, M.A.,Lu, J.,Miller, R.,Soisson, S.M.,Lam, M.H.,Fischer, C.; Mechanistic and Biostructural Studies of Mutant IDH1; To Be Published,

実験手法

X-RAY DIFFRACTION (2.26 Å)