8T7D

Crystal structure of wild type IDH1 bound to compound 1

Summary for 8T7D

• Entry DOI: 10.2210/pdb8t7d/pdb
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide (2 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 193872.67

Authors

Lu, J.,Abeywickrema, P.,Heo, M.R.,Parthasarathy, G.,McCoy, M.,Soisson, S.M. (deposition date: 2023-06-20, release date: 2024-08-28)

• Primary citation: McCoy, M.A.,Lu, J.,Miller, R.,Soisson, S.M.,Lam, M.H.,Fischer, C.; Mechanistic and Biostructural Studies of Mutant IDH1; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.444 Å)