8T6I

Structure of VHH-Fab complex with engineered Crystal Kappa region

Summary for 8T6I

• Entry DOI: 10.2210/pdb8t6i/pdb
• Descriptor: VHH domain, Fab light chain, Fab heavy chain, ... (5 entities in total)
• Functional Keywords: nabfab, nanobody, antibody fragment, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 62972.83

Authors

Filippova, E.V.,Thompson, I.,Kossiakoff, A.A. (deposition date: 2023-06-16, release date: 2023-11-29, Last modification date: 2024-01-03)

• Primary citation: Bruce, H.A.,Singer, A.U.,Filippova, E.V.,Blazer, L.L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.H.,Mao, D.Y.L.,Pau, V.,Orlicky, S.,Sicheri, F.,Kurinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S.; Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.; Protein Sci., 33:e4824-e4824, 2024; PubMed: 37945533; DOI: 10.1002/pro.4824

Experimental method

X-RAY DIFFRACTION (2.55 Å)