8T5V
Influenza PA-N Endonuclease A36V mutant with Baloxavir
Summary for 8T5V
Entry DOI | 10.2210/pdb8t5v/pdb |
Descriptor | Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid, ... (4 entities in total) |
Functional Keywords | influenza endonuclease, resistance, drug discovery, metal-binding pharmacophore, antiviral protein, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Influenza A virus (A/California/04/2009(H1N1)) |
Total number of polymer chains | 1 |
Total formula weight | 23045.97 |
Authors | |
Primary citation | Kohlbrand, A.J.,Stokes, R.W.,Sankaran, B.,Cohen, S.M. Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63:264-272, 2024 Cited by PubMed: 38190441DOI: 10.1021/acs.biochem.3c00536 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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