8T5E
De novo design of high-affinity protein binders to bioactive helical peptides
Summary for 8T5E
Entry DOI | 10.2210/pdb8t5e/pdb |
Descriptor | Bim_fulldiff, Bcl-2-like protein 11 (2 entities in total) |
Functional Keywords | alpha-helical peptides, protein design, diffusion, deep learning, de novo protein |
Biological source | synthetic construct More |
Total number of polymer chains | 2 |
Total formula weight | 19501.48 |
Authors | Torres, S.V.,Leung, P.J.Y.,Bera, A.K.,Baker, D.,Kang, A. (deposition date: 2023-06-13, release date: 2024-01-10, Last modification date: 2024-02-14) |
Primary citation | Vazquez Torres, S.,Leung, P.J.Y.,Venkatesh, P.,Lutz, I.D.,Hink, F.,Huynh, H.H.,Becker, J.,Yeh, A.H.,Juergens, D.,Bennett, N.R.,Hoofnagle, A.N.,Huang, E.,MacCoss, M.J.,Exposit, M.,Lee, G.R.,Bera, A.K.,Kang, A.,De La Cruz, J.,Levine, P.M.,Li, X.,Lamb, M.,Gerben, S.R.,Murray, A.,Heine, P.,Korkmaz, E.N.,Nivala, J.,Stewart, L.,Watson, J.L.,Rogers, J.M.,Baker, D. De novo design of high-affinity binders of bioactive helical peptides. Nature, 626:435-442, 2024 Cited by PubMed: 38109936DOI: 10.1038/s41586-023-06953-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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