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8T5A

HIV-1 Integrase Catalytic Core Domain (CCD) F185H/Y99H/A128T Mutant Complexed with STP03-0404

Summary for 8T5A
Entry DOI10.2210/pdb8t5a/pdb
DescriptorIntegrase, (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid (3 entities in total)
Functional Keywordsintegrase, viral protein
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains1
Total formula weight17265.19
Authors
Dinh, T.,Kvaratskhelia, M. (deposition date: 2023-06-12, release date: 2024-06-19, Last modification date: 2024-07-31)
Primary citationDinh, T.,Tber, Z.,Rey, J.S.,Mengshetti, S.,Annamalai, A.S.,Haney, R.,Briganti, L.,Amblard, F.,Fuchs, J.R.,Cherepanov, P.,Kim, K.,Schinazi, R.F.,Perilla, J.R.,Kim, B.,Kvaratskhelia, M.
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
Biorxiv, 2024
Cited by
PubMed: 38328097
DOI: 10.1101/2024.01.26.577387
PDB entries with the same primary citation
Experimental method
Structure validation

223790

건을2024-08-14부터공개중

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