8T5A
HIV-1 Integrase Catalytic Core Domain (CCD) F185H/Y99H/A128T Mutant Complexed with STP03-0404
Summary for 8T5A
Entry DOI | 10.2210/pdb8t5a/pdb |
Descriptor | Integrase, (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid (3 entities in total) |
Functional Keywords | integrase, viral protein |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 17265.19 |
Authors | Dinh, T.,Kvaratskhelia, M. (deposition date: 2023-06-12, release date: 2024-06-19, Last modification date: 2024-07-31) |
Primary citation | Dinh, T.,Tber, Z.,Rey, J.S.,Mengshetti, S.,Annamalai, A.S.,Haney, R.,Briganti, L.,Amblard, F.,Fuchs, J.R.,Cherepanov, P.,Kim, K.,Schinazi, R.F.,Perilla, J.R.,Kim, B.,Kvaratskhelia, M. The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir. Biorxiv, 2024 Cited by PubMed: 38328097DOI: 10.1101/2024.01.26.577387 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report