8SZV
Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog SJPYT-318
Summary for 8SZV
Entry DOI | 10.2210/pdb8szv/pdb |
Descriptor | Nuclear receptor subfamily 1 group I member 2, N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-[(4-phenoxyphenyl)methyl]benzenesulfonamide (3 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, metabolism, antibiotic, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 36790.27 |
Authors | Huber, A.D.,Poudel, S.,Miller, D.J.,Li, Y.,Chen, T. (deposition date: 2023-05-30, release date: 2023-10-11, Last modification date: 2023-12-20) |
Primary citation | Huber, A.D.,Poudel, S.,Li, Y.,Lin, W.,Wu, J.,Miller, D.J.,Chen, T. Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand. Structure, 31:1545-, 2023 Cited by PubMed: 37729916DOI: 10.1016/j.str.2023.08.020 PDB entries with the same primary citation |
Experimental method |
Structure validation
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