8SZV

Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog SJPYT-318

8SZV の概要

• エントリーDOI: 10.2210/pdb8szv/pdb
• 分子名称: Nuclear receptor subfamily 1 group I member 2, N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-[(4-phenoxyphenyl)methyl]benzenesulfonamide (3 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, metabolism, antibiotic, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36790.27

構造登録者

Huber, A.D.,Poudel, S.,Miller, D.J.,Li, Y.,Chen, T. (登録日: 2023-05-30, 公開日: 2023-10-11, 最終更新日: 2023-12-20)

• 主引用文献: Huber, A.D.,Poudel, S.,Li, Y.,Lin, W.,Wu, J.,Miller, D.J.,Chen, T.; Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.; Structure, 31:1545-, 2023; PubMed: 37729916; DOI: 10.1016/j.str.2023.08.020

実験手法

X-RAY DIFFRACTION (2.2 Å)