8SVP

Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-278

8SVP の概要

• エントリーDOI: 10.2210/pdb8svp/pdb
• 分子名称: Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide, (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, (1P)-N-(5-tert-butyl-2-{[(3R)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: pregnane x receptor (pxr), promiscuous ligand-activated protein, nuclear receptor subfamily 1, transcriptional regulator, and drug metabolism., transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81769.77

構造登録者

Garcia-Maldonado, E.,Huber, A.D.,Nithianantham, S.,Miller, D.J.,Chen, T. (登録日: 2023-05-17, 公開日: 2024-05-15, 最終更新日: 2024-05-29)

• 主引用文献: Garcia-Maldonado, E.,Huber, A.D.,Chai, S.C.,Nithianantham, S.,Li, Y.,Wu, J.,Poudel, S.,Miller, D.J.,Seetharaman, J.,Chen, T.; Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR.; Nat Commun, 15:4054-4054, 2024; PubMed: 38744881; DOI: 10.1038/s41467-024-48472-1

実験手法

X-RAY DIFFRACTION (3.32 Å)