8SVO
Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-310
Summary for 8SVO
Entry DOI | 10.2210/pdb8svo/pdb |
Descriptor | Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide, (1P)-N-(5-tert-butyl-2-{[(2S)-pentan-2-yl]oxy}phenyl)-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | pregnane x receptor (pxr), promiscuous ligand-activated protein, nuclear receptor subfamily 1, transcriptional regulator, and drug metabolism., transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 80798.60 |
Authors | Garcia-Maldonado, E.,Huber, A.D.,Nithianantham, S.,Miller, D.J.,Chen, T. (deposition date: 2023-05-17, release date: 2024-05-15, Last modification date: 2024-05-29) |
Primary citation | Garcia-Maldonado, E.,Huber, A.D.,Chai, S.C.,Nithianantham, S.,Li, Y.,Wu, J.,Poudel, S.,Miller, D.J.,Seetharaman, J.,Chen, T. Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15:4054-4054, 2024 Cited by PubMed: 38744881DOI: 10.1038/s41467-024-48472-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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