8SVL

Plasmodium falciparum M1 aminopeptidase bound to MMV1557817

8SVL の概要

• エントリーDOI: 10.2210/pdb8svl/pdb
• 分子名称: M1 family aminopeptidase, ZINC ION, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-3,3-dimethylbutanamide, ... (6 entities in total)
• 機能のキーワード: metallo-exopeptidase; protease inhibitor, malaria, plasmodium, m1 aminopeptidase, hydrolase
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 128413.88

構造登録者

McGowan, S.,Drinkwater, N. (登録日: 2023-05-17, 公開日: 2024-04-24)

• 主引用文献: de Koning-Ward, T.F.,Drinkwater, N.,Edgar, R.C.S.,McGowan, S.,Scammells, P.J.; Characterisation of a novel antimalarial agent targeting haemaglobin digestion that shows cross-species reactivity and excellent in vivo properties.; Mbio, 2024

実験手法

X-RAY DIFFRACTION (1.504 Å)