8SVJ

Ubiquitin variant i53: mutant VHH with 53BP1 Tudor domain

8SVJ の概要

• エントリーDOI: 10.2210/pdb8svj/pdb
• 分子名称: Tumor protein p53 binding protein 1, Ubiquitin varient i53 mutant VHH, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: inhibitor, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22728.82

構造登録者

Holden, J.,Partridge, J.R.,Wibowo, A.S.,Mulichak, A. (登録日: 2023-05-16, 公開日: 2024-03-27, 最終更新日: 2024-04-03)

• 主引用文献: Perez-Bermejo, J.A.,Efagene, O.,Matern, W.M.,Holden, J.K.,Kabir, S.,Chew, G.M.,Andreoletti, G.,Catton, E.,Ennis, C.L.,Garcia, A.,Gerstenberg, T.L.,Hill, K.A.,Jain, A.,Krassovsky, K.,Lalisan, C.D.,Lord, D.,Quejarro, B.J.,Sales-Lee, J.,Shah, M.,Silva, B.J.,Skowronski, J.,Strukov, Y.G.,Thomas, J.,Veraz, M.,Vijay, T.,Wallace, K.A.,Yuan, Y.,Grogan, J.L.,Wienert, B.,Lahiri, P.,Treusch, S.,Dever, D.P.,Soros, V.B.,Partridge, J.R.,Seim, K.L.; Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.; Nat Commun, 15:2625-2625, 2024; PubMed: 38521763; DOI: 10.1038/s41467-024-46816-5

実験手法

X-RAY DIFFRACTION (1.5 Å)