8SS6
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state)
Summary for 8SS6
Entry DOI | 10.2210/pdb8ss6/pdb |
EMDB information | 40745 |
Descriptor | Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, Protein cornichon homolog 2, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, ... (8 entities in total) |
Functional Keywords | ampa receptor, spermidine, perampanel, cornichon-2, signaling protein |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 6 |
Total formula weight | 526147.69 |
Authors | Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2023-05-08, release date: 2023-09-06, Last modification date: 2023-11-01) |
Primary citation | Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Korman, A.,Jones, D.R.,Sobolevsky, A.I. Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30:1481-1494, 2023 Cited by PubMed: 37653241DOI: 10.1038/s41594-023-01080-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.01 Å) |
Structure validation
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