8SS6

Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state)

8SS6 の概要

• エントリーDOI: 10.2210/pdb8ss6/pdb
• EMDBエントリー: 40745
• 分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, Protein cornichon homolog 2, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, ... (8 entities in total)
• 機能のキーワード: ampa receptor, spermidine, perampanel, cornichon-2, signaling protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 526147.69

構造登録者

Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. (登録日: 2023-05-08, 公開日: 2023-09-06, 最終更新日: 2023-11-01)

• 主引用文献: Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Korman, A.,Jones, D.R.,Sobolevsky, A.I.; Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.; Nat.Struct.Mol.Biol., 30:1481-1494, 2023; PubMed: 37653241; DOI: 10.1038/s41594-023-01080-x

実験手法

ELECTRON MICROSCOPY (3.01 Å)