8SS2

Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)

8SS2 の概要

• エントリーDOI: 10.2210/pdb8ss2/pdb
• EMDBエントリー: 40741
• 分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, Protein cornichon homolog 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, ... (7 entities in total)
• 機能のキーワード: ampa receptor, spermidine, tarp gamma-5, cornichon-2, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 523291.62

構造登録者

Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. (登録日: 2023-05-08, 公開日: 2023-09-06, 最終更新日: 2023-11-01)

• 主引用文献: Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Korman, A.,Jones, D.R.,Sobolevsky, A.I.; Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.; Nat.Struct.Mol.Biol., 30:1481-1494, 2023; PubMed: 37653241; DOI: 10.1038/s41594-023-01080-x

実験手法

ELECTRON MICROSCOPY (3.58 Å)