8SRA

Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium

Summary for 8SRA

Entry DOI	10.2210/pdb8sra/pdb
EMDB information	40724 40877
Descriptor	TRPM2 chanzyme, CALCIUM ION, CHOLESTEROL (3 entities in total)
Functional Keywords	trpm2 chanzyme, channel-enzyme, transport protein
Biological source	Salpingoeca rosetta
Total number of polymer chains	4
Total formula weight	677970.41
Authors	Huang, Y.,Kumar, S.,Lu, W.,Du, J. (deposition date: 2023-05-05, release date: 2024-05-08, Last modification date: 2024-06-05)
Primary citation	Huang, Y.,Kumar, S.,Lee, J.,Lu, W.,Du, J. Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38773335 DOI: 10.1038/s41594-024-01316-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.93 Å)

Structure validation