8SQF
OXA-48 bound to inhibitor CDD-2725
Summary for 8SQF
Entry DOI | 10.2210/pdb8sqf/pdb |
Descriptor | Beta-lactamase, (1M)-3'-(benzyloxy)-5-hydroxy[1,1'-biphenyl]-3,4'-dicarboxylic acid, BICARBONATE ION, ... (4 entities in total) |
Functional Keywords | carbapenemase, beta-lactamase, small molecule, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 61730.18 |
Authors | Park, S.,Judge, A.,Fan, J.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2023-05-04, release date: 2024-01-03, Last modification date: 2024-01-17) |
Primary citation | Park, S.,Fan, J.,Chamakuri, S.,Palaniappan, M.,Sharma, K.,Qin, X.,Wang, J.,Tan, Z.,Judge, A.,Hu, L.,Sankaran, B.,Li, F.,Prasad, B.V.V.,Matzuk, M.M.,Palzkill, T. Exploiting the Carboxylate-Binding Pocket of beta-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J.Med.Chem., 67:620-642, 2024 Cited by PubMed: 38117688DOI: 10.1021/acs.jmedchem.3c01834 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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