8SN5

Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 3)

8SN5 の概要

• エントリーDOI: 10.2210/pdb8sn5/pdb
• EMDBエントリー: 40613
• 分子名称: Histone H3.1, ZINC ION, Histone H4, ... (10 entities in total)
• 機能のキーワード: nucleosome core particle, chromatin, rnf168, ring domain, ubch5c, dna repair, dna double-strand break, homologous recombination, 53bp1, ubiquitin, structural protein-dna-transferase complex, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 13
• 化学式量合計: 238148.07

構造登録者

Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, G.,Mer, G. (登録日: 2023-04-26, 公開日: 2024-01-17, 最終更新日: 2024-03-20)

• 主引用文献: Hu, Q.,Zhao, D.,Cui, G.,Bhandari, J.,Thompson, J.R.,Botuyan, M.V.,Mer, G.; Mechanisms of RNF168 nucleosome recognition and ubiquitylation.; Mol.Cell, 84:839-853.e12, 2024; PubMed: 38242129; DOI: 10.1016/j.molcel.2023.12.036

実験手法

ELECTRON MICROSCOPY (3.9 Å)