8SLZ

Crystal structure of phosphorylated (T357/S358) human MLKL pseudokinase domain

8SLZ の概要

• エントリーDOI: 10.2210/pdb8slz/pdb
• 分子名称: Mixed lineage kinase domain-like protein (2 entities in total)
• 機能のキーワード: pseudokinase, phosphorylation, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32896.71

構造登録者

Meng, Y.,Davies, K.A.,Czabotar, P.E.,Murphy, J.M. (登録日: 2023-04-25, 公開日: 2023-11-08)

• 主引用文献: Meng, Y.,Garnish, S.E.,Davies, K.A.,Black, K.A.,Leis, A.P.,Horne, C.R.,Hildebrand, J.M.,Hoblos, H.,Fitzgibbon, C.,Young, S.N.,Dite, T.,Dagley, L.F.,Venkat, A.,Kannan, N.,Koide, A.,Koide, S.,Glukhova, A.,Czabotar, P.E.,Murphy, J.M.; Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.; Nat Commun, 14:6804-6804, 2023; PubMed: 37884510; DOI: 10.1038/s41467-023-42255-w

実験手法

X-RAY DIFFRACTION (2.3 Å)