8SLO

Plasmodium falciparum M1 aminopeptidase bound to selective inhibitor MIPS2673

8SLO の概要

• エントリーDOI: 10.2210/pdb8slo/pdb
• 分子名称: M1 family aminopeptidase, ZINC ION, 2-hydroxy-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-2-methylpropanamide, ... (6 entities in total)
• 機能のキーワード: plasmodium falciparum, malaria, metallo-exopeptidase, m1 aminopeptidase, aminopeptidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 127849.26

構造登録者

McGowan, S.M.,Drinkwater, N. (登録日: 2023-04-24, 公開日: 2024-04-03)

• 主引用文献: Giannangelo, C.,Drinkwater, N.,Edgar, R.,Malcolm, T.R.,Siddiqui, G.,Scammells, P.J.,De Koning-Ward, T.F.,McGowan, S.,Creek, D.; Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as a cross-species strategy to treat malaria; Elife, 2024; DOI: 10.7554/eLife.92990.1

実験手法

X-RAY DIFFRACTION (1.55 Å)