8SKQ
RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA)
Summary for 8SKQ
Entry DOI | 10.2210/pdb8skq/pdb |
Descriptor | TNA-containing RNA oligonucleotide (2 entities in total) |
Functional Keywords | tna, rna, oligonucleotide |
Biological source | synthetic construct |
Total number of polymer chains | 1 |
Total formula weight | 3993.15 |
Authors | |
Primary citation | Matsuda, S.,Bala, S.,Liao, J.Y.,Datta, D.,Mikami, A.,Woods, L.,Harp, J.M.,Gilbert, J.A.,Bisbe, A.,Manoharan, R.M.,Kim, M.,Theile, C.S.,Guenther, D.C.,Jiang, Y.,Agarwal, S.,Maganti, R.,Schlegel, M.K.,Zlatev, I.,Charisse, K.,Rajeev, K.G.,Castoreno, A.,Maier, M.,Janas, M.M.,Egli, M.,Chaput, J.C.,Manoharan, M. Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. J.Am.Chem.Soc., 145:19691-19706, 2023 Cited by PubMed: 37638886DOI: 10.1021/jacs.3c04744 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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