8SKQ

RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA)

Summary for 8SKQ

Entry DOI	10.2210/pdb8skq/pdb
Descriptor	TNA-containing RNA oligonucleotide (2 entities in total)
Functional Keywords	tna, rna, oligonucleotide
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	3993.15
Authors	Harp, J.M.,Egli, M. (deposition date: 2023-04-20, release date: 2024-02-14)
Primary citation	Matsuda, S.,Bala, S.,Liao, J.Y.,Datta, D.,Mikami, A.,Woods, L.,Harp, J.M.,Gilbert, J.A.,Bisbe, A.,Manoharan, R.M.,Kim, M.,Theile, C.S.,Guenther, D.C.,Jiang, Y.,Agarwal, S.,Maganti, R.,Schlegel, M.K.,Zlatev, I.,Charisse, K.,Rajeev, K.G.,Castoreno, A.,Maier, M.,Janas, M.M.,Egli, M.,Chaput, J.C.,Manoharan, M. Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. J.Am.Chem.Soc., 145:19691-19706, 2023 Cited by PubMed: 37638886 DOI: 10.1021/jacs.3c04744 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation