8SKQ

RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA)

8SKQ の概要

• エントリーDOI: 10.2210/pdb8skq/pdb
• 分子名称: TNA-containing RNA oligonucleotide (2 entities in total)
• 機能のキーワード: tna, rna, oligonucleotide
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3993.15

構造登録者

Harp, J.M.,Egli, M. (登録日: 2023-04-20, 公開日: 2024-02-14)

• 主引用文献: Matsuda, S.,Bala, S.,Liao, J.Y.,Datta, D.,Mikami, A.,Woods, L.,Harp, J.M.,Gilbert, J.A.,Bisbe, A.,Manoharan, R.M.,Kim, M.,Theile, C.S.,Guenther, D.C.,Jiang, Y.,Agarwal, S.,Maganti, R.,Schlegel, M.K.,Zlatev, I.,Charisse, K.,Rajeev, K.G.,Castoreno, A.,Maier, M.,Janas, M.M.,Egli, M.,Chaput, J.C.,Manoharan, M.; Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.; J.Am.Chem.Soc., 145:19691-19706, 2023; PubMed: 37638886; DOI: 10.1021/jacs.3c04744

実験手法

X-RAY DIFFRACTION (1.35 Å)