8SJW

[4T28] Self-assembling right-handed tensegrity triangle with 28 interjunction base pairs and R3 symmetry

8SJW の概要

• エントリーDOI: 10.2210/pdb8sjw/pdb
• 分子名称: DNA (5'-D(P*CP*AP*TP*CP*TP*AP*GP*CP*TP*CP*GP*TP*GP*GP*AP*CP*TP*GP*AP*T)-3'), DNA (5'-D(*TP*CP*AP*TP*CP*AP*GP*TP*GP*GP*CP*AP*GP*T)-3'), DNA (5'-D(*GP*AP*AP*CP*TP*GP*CP*CP*TP*GP*AP*AP*TP*TP*AP*CP*TP*GP*AP*CP*CP*G)-3'), ... (4 entities in total)
• 機能のキーワード: tensegrity triangle, dna nanotechnology, nanomaterials, dna
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 25771.70

構造登録者

Janowski, J.,Vecchioni, S.,Sha, R.,Ohayon, Y.P. (登録日: 2023-04-18, 公開日: 2024-04-24, 最終更新日: 2024-05-08)

主引用文献

Janowski, J.,Pham, V.A.B.,Vecchioni, S.,Woloszyn, K.,Lu, B.,Zou, Y.,Erkalo, B.,Perren, L.,Rueb, J.,Madnick, J.,Mao, C.,Saito, M.,Ohayon, Y.P.,Jonoska, N.,Sha, R.
Engineering tertiary chirality in helical biopolymers.
Proc.Natl.Acad.Sci.USA, 121:e2321992121-e2321992121, 2024

PubMed Abstract: Tertiary chirality describes the handedness of supramolecular assemblies and relies not only on the primary and secondary structures of the building blocks but also on topological driving forces that have been sparsely characterized. Helical biopolymers, especially DNA, have been extensively investigated as they possess intrinsic chirality that determines the optical, mechanical, and physical properties of the ensuing material. Here, we employ the DNA tensegrity triangle as a model system to locate the tipping points in chirality inversion at the tertiary level by X-ray diffraction. We engineer tensegrity triangle crystals with incremental rotational steps between immobile junctions from 3 to 28 base pairs (bp). We construct a mathematical model that accurately predicts and explains the molecular configurations in both this work and previous studies. Our design framework is extendable to other supramolecular assemblies of helical biopolymers and can be used in the design of chiral nanomaterials, optically active molecules, and mesoporous frameworks, all of which are of interest to physical, biological, and chemical nanoscience.

PubMed: 38684000
DOI: 10.1073/pnas.2321992121

実験手法

X-RAY DIFFRACTION (7.64 Å)