8SJK

Pembrolizumab Caffeine crystal

Summary for 8SJK

• Entry DOI: 10.2210/pdb8sjk/pdb
• Related PRD ID: PRD_900003
• Descriptor: ANTIBODY LIGHT CHAIN, ANTIBODY HEAVY CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: cancer, antibody, subclasses, igg4, melanoma, nsclc, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 75130.49

Authors

Larpent, P.,Codan, L.,Bothe, J.R.,Stueber, D.,Reichert, P.,Fischmann, T.,Su, Y.,Pabit, S.,Gupta, S.,Iuzzolino, L.,Cote, A. (deposition date: 2023-04-18, release date: 2024-04-24, Last modification date: 2024-08-21)

• Primary citation: Larpent, P.,Codan, L.,Bothe, J.R.,Iuzzolino, L.,Pabit, S.,Gupta, S.,Fischmann, T.,Su, Y.,Reichert, P.,Stueber, D.,Cote, A.; Small-Angle X-ray Scattering as a Powerful Tool for Phase and Crystallinity Assessment of Monoclonal Antibody Crystallites in Support of Batch Crystallization.; Mol Pharm., 21:4024-4037, 2024; PubMed: 38958508; DOI: 10.1021/acs.molpharmaceut.4c00418

Experimental method

X-RAY DIFFRACTION (2.22 Å)