8SJK

Pembrolizumab Caffeine crystal

8SJK の概要

• エントリーDOI: 10.2210/pdb8sjk/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: ANTIBODY LIGHT CHAIN, ANTIBODY HEAVY CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: cancer, antibody, subclasses, igg4, melanoma, nsclc, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75130.49

構造登録者

Larpent, P.,Codan, L.,Bothe, J.R.,Stueber, D.,Reichert, P.,Fischmann, T.,Su, Y.,Pabit, S.,Gupta, S.,Iuzzolino, L.,Cote, A. (登録日: 2023-04-18, 公開日: 2024-04-24, 最終更新日: 2024-08-21)

• 主引用文献: Larpent, P.,Codan, L.,Bothe, J.R.,Iuzzolino, L.,Pabit, S.,Gupta, S.,Fischmann, T.,Su, Y.,Reichert, P.,Stueber, D.,Cote, A.; Small-Angle X-ray Scattering as a Powerful Tool for Phase and Crystallinity Assessment of Monoclonal Antibody Crystallites in Support of Batch Crystallization.; Mol Pharm., 21:4024-4037, 2024; PubMed: 38958508; DOI: 10.1021/acs.molpharmaceut.4c00418

実験手法

X-RAY DIFFRACTION (2.22 Å)