8SIS

Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.2 Fab

8SIS の概要

• エントリーDOI: 10.2210/pdb8sis/pdb
• 分子名称: Spike protein S1, CC84.2 Fab heavy chain, CC84.2 Fab light chain, ... (4 entities in total)
• 機能のキーワード: bnab, sars-cov-2, broadly neutralizing antibody, spike, rbd, immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 71862.07

構造登録者

Liu, H.,Wilson, I.A. (登録日: 2023-04-16, 公開日: 2024-03-13)

• 主引用文献: Song, G.,Yuan, M.,Liu, H.,Capozzola, T.,Lin, R.,Torres, J.,He, W.,Musharrafieh, R.,Dueker, K.,Zhou, P.,Callaghan, S.,Mishra, N.,Yong, P.,Anzanello, F.,Avillion, G.,Vo, A.,Li, X.,Makhdoomi, M.,Feng, Z.,Zhu, X.,Peng, L.,Nemazee, D.,Safonova, Y.,Briney, B.,Ward, A.,Burton, D.,Wilson, I.,Andrabi, R.; Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift; Biorxiv, 2023; DOI: 10.1101/2023.04.26.538488

実験手法

X-RAY DIFFRACTION (3.08 Å)