8SI5

Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in open state

8SI5 の概要

• エントリーDOI: 10.2210/pdb8si5/pdb
• 関連するPDBエントリー: 8SI2 8SI3 8SI4
• EMDBエントリー: 40496 40497 40498 40499
• 分子名称: Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, ... (7 entities in total)
• 機能のキーワード: transient receptor potential m family member 7, trp, channel, trpm7, open state, trp channels, membrane protein, magnesium channel, agonist, ligand, naltriben
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 632395.08

構造登録者

Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (登録日: 2023-04-14, 公開日: 2023-05-17)

• 主引用文献: Nadezhdin, K.D.,Correia, L.,Narangoda, C.,Patel, D.S.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I.; Structural mechanisms of TRPM7 activation and inhibition.; Nat Commun, 14:2639-2639, 2023; PubMed: 37156763; DOI: 10.1038/s41467-023-38362-3

実験手法

ELECTRON MICROSCOPY (2.17 Å)