8SH1
Structure of human POT1 DNA binding domain bound to a 5'-phosphorylated junction of a telomeric double-stranded DNA duplex with a 3'-overhang
Summary for 8SH1
Entry DOI | 10.2210/pdb8sh1/pdb |
Descriptor | Protection of telomeres protein 1, DNA (5'-D(*CP*GP*CP*GP*CP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*CP*GP*CP*GP*CP*G)-3'), ... (4 entities in total) |
Functional Keywords | shelterin, telomere, dna junction, 5'-phosphorylated, pot-hole, chromosome end protection, pot1, dbd, pot1-dna complex, dna binding protein, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 43721.25 |
Authors | |
Primary citation | Tesmer, V.M.,Brenner, K.A.,Nandakumar, J. Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome. Science, 381:771-778, 2023 Cited by PubMed: 37590346DOI: 10.1126/science.adi2436 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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