8SH1

Structure of human POT1 DNA binding domain bound to a 5'-phosphorylated junction of a telomeric double-stranded DNA duplex with a 3'-overhang

8SH1 の概要

• エントリーDOI: 10.2210/pdb8sh1/pdb
• 分子名称: Protection of telomeres protein 1, DNA (5'-D(*CP*GP*CP*GP*CP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*CP*GP*CP*GP*CP*G)-3'), ... (4 entities in total)
• 機能のキーワード: shelterin, telomere, dna junction, 5'-phosphorylated, pot-hole, chromosome end protection, pot1, dbd, pot1-dna complex, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 43721.25

構造登録者

Nandakumar, J.,Tesmer, V.M. (登録日: 2023-04-13, 公開日: 2023-08-30)

• 主引用文献: Tesmer, V.M.,Brenner, K.A.,Nandakumar, J.; Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.; Science, 381:771-778, 2023; PubMed: 37590346; DOI: 10.1126/science.adi2436

実験手法

X-RAY DIFFRACTION (2.6 Å)