8SDQ
ATAD2 bromodomain in complex with H4S1phK5ac (res 1-15) ligand
Summary for 8SDQ
Entry DOI | 10.2210/pdb8sdq/pdb |
Descriptor | ATPase family AAA domain-containing protein 2, Histone H4 (3 entities in total) |
Functional Keywords | bromodomain, epigenetics, nuclear protein, cancer, histone, acetylation, protein binding |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 19269.69 |
Authors | Malone, K.L.,Nix, J.C.,Glass, K.C. (deposition date: 2023-04-07, release date: 2024-06-05, Last modification date: 2024-10-16) |
Primary citation | Phillips, M.,Malone, K.L.,Boyle, B.W.,Montgomery, C.,Kressy, I.A.,Joseph, F.M.,Bright, K.M.,Boyson, S.P.,Chang, S.,Nix, J.C.,Young, N.L.,Jeffers, V.,Frietze, S.,Glass, K.C. Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains. J.Med.Chem., 67:8186-8200, 2024 Cited by PubMed: 38733345DOI: 10.1021/acs.jmedchem.4c00210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report