8SDN
Crystal structure of PDC-3 Y221H beta-lactamase
Summary for 8SDN
Entry DOI | 10.2210/pdb8sdn/pdb |
Descriptor | Beta-lactamase, ISOPROPYL ALCOHOL (3 entities in total) |
Functional Keywords | pseudomonas-derived cephalosporinase, antibiotic resistance, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 43454.26 |
Authors | Kumar, V.,van den Akker, F. (deposition date: 2023-04-07, release date: 2023-08-16, Last modification date: 2023-11-22) |
Primary citation | Mack, A.R.,Kumar, V.,Taracila, M.A.,Mojica, M.F.,O'Shea, M.,Schinabeck, W.,Silver, G.,Hujer, A.M.,Papp-Wallace, K.M.,Chen, S.,Haider, S.,Caselli, E.,Prati, F.,van den Akker, F.,Bonomo, R.A. Natural protein engineering in the Omega-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase. Antimicrob.Agents Chemother., 67:e0079123-e0079123, 2023 Cited by PubMed: 37850746DOI: 10.1128/aac.00791-23 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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