8SDN

Crystal structure of PDC-3 Y221H beta-lactamase

Summary for 8SDN

• Entry DOI: 10.2210/pdb8sdn/pdb
• Descriptor: Beta-lactamase, ISOPROPYL ALCOHOL (3 entities in total)
• Functional Keywords: pseudomonas-derived cephalosporinase, antibiotic resistance, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 43454.26

Authors

Kumar, V.,van den Akker, F. (deposition date: 2023-04-07, release date: 2023-08-16, Last modification date: 2023-11-22)

• Primary citation: Mack, A.R.,Kumar, V.,Taracila, M.A.,Mojica, M.F.,O'Shea, M.,Schinabeck, W.,Silver, G.,Hujer, A.M.,Papp-Wallace, K.M.,Chen, S.,Haider, S.,Caselli, E.,Prati, F.,van den Akker, F.,Bonomo, R.A.; Natural protein engineering in the Omega-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase.; Antimicrob.Agents Chemother., 67:e0079123-e0079123, 2023; PubMed: 37850746; DOI: 10.1128/aac.00791-23

Experimental method

X-RAY DIFFRACTION (2.1 Å)