8SC6
Human OCT1 bound to thiamine in inward-open conformation
Summary for 8SC6
Entry DOI | 10.2210/pdb8sc6/pdb |
EMDB information | 40339 |
Descriptor | Solute carrier family 22 member 1, 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM (2 entities in total) |
Functional Keywords | membrane protein, mfs, drug transporter, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 61466.02 |
Authors | Zeng, Y.C.,Sobti, M.,Stewart, A.G. (deposition date: 2023-04-04, release date: 2023-10-18, Last modification date: 2023-10-25) |
Primary citation | Zeng, Y.C.,Sobti, M.,Quinn, A.,Smith, N.J.,Brown, S.H.J.,Vandenberg, J.I.,Ryan, R.M.,O'Mara, M.L.,Stewart, A.G. Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. Nat Commun, 14:6374-6374, 2023 Cited by PubMed: 37821493DOI: 10.1038/s41467-023-42086-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.13 Å) |
Structure validation
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