8S5W

Cryo-EM structure of fedratinib-bound human SLC19A3 in inward-open state

Summary for 8S5W

• Entry DOI: 10.2210/pdb8s5w/pdb
• EMDB information: 19752
• Descriptor: Nb3.7, Thiamine transporter 2, N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide (3 entities in total)
• Functional Keywords: slc19a3, vitamin transporter, thiamine transporter, mfs fold, nanobody complex, membrane protein
• Biological source: Lama glama; More
• Total number of polymer chains: 2
• Total formula weight: 75554.20

Authors

Gabriel, F.,Loew, C. (deposition date: 2024-02-26, release date: 2024-10-02, Last modification date: 2024-10-16)

• Primary citation: Gabriel, F.,Spriestersbach, L.,Fuhrmann, A.,Jungnickel, K.E.J.,Mostafavi, S.,Pardon, E.,Steyaert, J.,Low, C.; Structural basis of thiamine transport and drug recognition by SLC19A3.; Nat Commun, 15:8542-8542, 2024; PubMed: 39358356; DOI: 10.1038/s41467-024-52872-8

Experimental method

ELECTRON MICROSCOPY (3.05 Å)